By Nasuhi Engin AydinA herbal product has promising results in experimental endometriosis
By Nasuhi Engin Aydin
Neroli oil (bitter orange) is a nontoxic volatile substance from the flowers of Citrus aurantium that belongs to the Rutaceae family. This oil has notable anti-inflammatory effects besides potent antioxidant activity with 100% singlet oxygen scavenging activity. Contemporary pathophysiological views…
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By Selma OransayElevated iron levels in "endometriosis pathogenesis"
By Selma Oransay
The presence of abnormal levels of iron and ferritin in endometriotic lesions is likely due to repeated bleeding episodes. When red blood cells break down, the iron content is released, which can cause inflammation leading to damage to surrounding tissues.…
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Endometriosis and Progesterone Resistance
By Selma Oransay
Progesterone resistance is the unresponsiveness of endometrium with subsequent dysregulation of the progesterone signaling pathway, and endometrial gene works. Progestins, on the other hand, are the first-line treatment choice, especially for long-term treatment of endometriosis. In the clinics, one-third of…
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Scientific unfolding will lead new drug targets
By Nasuhi Engin Aydin
Drs. Dolmans and Donnez from academic institutions located in Brussels, Belgium, have published their comprehensive review on the current pathophysiological concepts in endometriosis with possible drug treatment potentials in the recent issue of a scientific journal named “Biomolecules”. As a…
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By Bahar YukselIs endometriosis an oxidative stress-induced inflammation?
By Bahar Yuksel
The roots of endometriosis are still controversial, but the effects of inflammation and oxidative stress have been accepted by scientific authorities. In the review conducted by Lauren Clower et al, the studies about oxidative stress and endometriosis have been analyzed.…
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The role of oxidative stress on endometriosis symptomatology
By Bahar Yuksel
Endometriosis is not only a hormonal disease, but it is also an inflammatory illness provoked by hormones. In the review conducted by Hossein Ansariniya et al., from Iran, the relation between oxidative stress, free radicals, free iron, and the development of…
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Envorinmental metals harmful for female reproductivity
By Selma Oransay
Heavy metals exposure in a wide range of ways is one of the main causes of increased infertility. According to the 2003 National Health Survey, nearly every pregnant woman in the USA is exposed to at least 43 hazardous chemicals…
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By Eylül GÜN“Sirtuin-3” as a novel target in endometriosis pathogenesis
By Eylül GÜN
The energy that is needed for a normal cell function is produced in the mitochondria. While producing this energy, a complex and cyclical process occurs with many proteins and enzymes. Enzymes such as glutamate dehydrogenase and succinate dehydrogenase play important…
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By Hale Goksever CelikThe higher the cyst fluid iron concentration, the more severe the pain symptom for endometrioma
By Hale Goksever Celik
Endometriosis usually is encountered in three different forms: superficial peritoneal endometriosis, ovarian cysts (endometrioma) and deep infiltrating endometriosis. Endometrioma can be identified as cystic lesions consisting of dark brown endometrial fluid and are sometimes referred to as "chocolate cysts." The presence…
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Antioxidant therapy for the endometriosis pain
By Selma Oransay
Ts the protective defense mechanism of cells, hence the destruction of balance between oxidants and antioxidants in our body is called "redox imbalance". The major oxidants are reactive oxygen species (ROS) that are involved in multiple cellular processes by physiologically…
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By Ellen TumimbangOxidative stress, reactive products, detoxification, endometriosis and pain
By Ellen Tumimbang
Oxidative stress is one factor known to be involved in the pathogenesis, progression, and establishment of endometriosis in women. During oxidative stress, excess reactive oxygen species as a secondary by-product of lipid peroxidation and reactive aldehyde including 4- hydroxynonenal…
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By Yu YuThe "metabolome" of follicular fluid in deep infiltrating endometriosis
By Yu Yu
Endometriosis encompasses three different phenotypes, being superficial endometriosis, deep infiltrating endometriosis (DIE), and ovarian endometrioma (OMA). The latter is the most severe form and has an unfavorable impact on ovarian function. Infertility associated with endometriosis has been linked to chronic…
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By Özge ÖzkayaCould Cosmetics and Personal Care Products Increase the Risk of Endometriosis?
By Özge Özkaya
The use of cosmetics and personal care products may be increasing the risk of endometriosis according to a study by Spanish researchers that was published in the journal "Environmental Research". This finding suggests that restricting the use of these products may…
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By Dr. Youngran ParkAntioxidant Enzymes in Endometriosis
By Dr. Youngran Park
Recent attention has been focused on the effect of oxidative stress in the development of endometriosis. Especially, there are several studies regarding glutathione peroxidase (GPX), a major enzyme in removing various reactive oxygen species. In the field of infertility, the…
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Oxidative stress leads to elevated cytokines, excessive structural damage and angiogenesis
By Yu Yu
Endometriosis is characterized by elevated intracellular reactive oxygen species, which is then believed to upregulate inflammatory cytokines. Reactive oxygen species also regulate the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which is closely linked with immune responses.…
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Fertility and Oxidative Stress
By Yu Yu
One of the characteristics of endometriosis is oxidative stress caused by an imbalance between the production of reactive oxygen species and their resolution by antioxidants. Increased oxidative stress can lead to the damage of proteins, lipids, DNA and other molecules.…
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Endometriosis and atherosclerotic cardiovascular disease
By Selma Oransay
Endometriosis and atherosclerotic cardiovascular disease show the same pathologic mechanism in terms of endothelial dysfunction. Tan et al. from the Department of Obstetrics and Gynecology, the University of British Columbia, Vancouver, Canada reviewed the literature aiming to determine whether women…
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The role of inflammation, oxidative stress, angiogenesis, and apoptosis in the pathophysiology of endometriosis
By Dr. Youngran Park
Endometriosis is a very common gynecological disorder affecting approximately 10% of reproductive-aged women, and it is known by the abnormal growth of endometrial stroma and glands outside the uterus. Though the pathogenesis of endometriosis is not clearly understood so far,…
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Does ovarian endometriosis affect oocyte quality?
By Dr. Youngran Park
Endometriosis is a very common gynecological disorder affecting women in their reproductive years. It is reported that patients with endometriosis have reduced implantation and pregnancy rates compared to healthy women. According to the various previous studies, the quality of the…
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Searching new biomarkers for endometriosis
By Selma Oransay
This recent article published in Advances in Clinical Chemistry, is an overall summary of characteristics, physiopathological theories, diagnostic approaches and variety of biomarkers to diagnose endometriosis and penned by Coutinho et al. from Universidade Federal de Juiz de Fora, Belo Horizonte,…
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By Irem OnurThe relationship between periodontal disease and endometriosis
By Irem Onur
Thomas et al. have recently studied the association between endometriosis and periodontal disease which may share a common pathogenesis, and have published it in the Journal of Human Reproductive Sciences. The authors screened a total of50 women; 25 with and 25…
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Is Physical Exercise Effective in Endometriosis?
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial tissue outside the uterine cavity. Dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility are mostly encountered symptoms of endometriosis. Although there are several theories explaining the pathogenesis of endometriosis, the exact pathogenesis still has…
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Vitamin C supplementation in the patients with endometriosis undergoing in vitro fertilization-embryo transfer
By Hale Goksever Celik
Endometriosis is defined as the localization of endometrial stromal and glandular cells outside the uterine cavity. Women having endometriosis present with dysmenorrhea, dyspareunia, chronic pelvic pain, and infertility. Thus, infertility remains a significant problem for women with endometriosis. Endometriosis is…
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By Murat OsmanOxidative Stress and Endometriosis
By Murat Osman
Endometriosis is a disease characterized by ectopic endometrial tissue outside the endometrium and is associated with a background of a chronic inflammation. Recent studies have aimed to elucidate the inflammatory mediators involved in endometriotic lesions by studying immune cell interactions,…
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N-acetyl cysteine, alpha lipoic acid and bromelain improved endometriosis-associated pelvic pain
By Yu Yu
Oxidative stress has been implicated in many processes that lead to the development and progression of endometriosis. Typically, women with endometriosis have to endure pelvic pain which negatively impacts their quality of life. Pelvic pain can be chronic and related…
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Detecting endometriosis using peripheral blood
By Yu Yu
Laparoscopic visualization of endometriotic lesions with histological confirmation is the gold standard for the diagnosis of endometriosis. However, this diagnostic procedure, due to the need for laparoscopy and variability of disease/symptoms, can have a major delay up to 8-10 years…
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Expert discussion on mechanisms of endometriosis development and progression
By Yu Yu
Several mechanisms have been proposed to explain the occurrence and worsening of endometriosis. Classically, it is believed that retrograde menstruation causes endometriosis. However, the presence of endometriosis in newly menarcheal or pre-menarcheal girls cannot fully explain this early onset endometriosis.…
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Another Marker to Predict the Outcome of IVF for Women with Endometriosis
By Özge Özkaya
AOPPs or advanced oxidative protein products may be new markers to predict egg quality and the outcomes of IVF in infertile women with endometriosis according to a study published in the journal Experimental and Therapeutic Medicine. This finding suggests that anti-oxidative treatments…
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Endometriosis pathogenesis through the lens of reactive oxygen species
By Yu Yu
Oxidative stress caused by reactive oxygen species is an essential factor in endometriosis pathogenesis. The harmful effects of reactive oxygen species have been implicated in many diseases, although the multiple biological changes caused is unclear especially in endometriosis. The article…
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Endometriosis and Oxidative Stress
By Dr. Youngran Park
The etiology of endometriosis is still unclear. However, it is now widely accepted that oxidative stress, defined as an imbalance between reactive oxygen species (ROS) and antioxidants, may be implicated in the pathophysiology of endometriosis causing a general inflammatory response…
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By Kasthuri NairA Two-Wave Molecular Mechanism for Endometriosis Disease Progression
By Kasthuri Nair
Kobayashi et al. recently published a review paper in Molecular Medicine Reports titled “Pathogenesis of endometriosis: The role of initial infection and subsequent sterile inflammation,” which discusses at length the role of non-specific bacterial infection and sterile inflammation in the…
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Agents Causing Red Blood Cell Lysis Worsens Endometriosis
By Kasthuri Nair
Endometriosis is a painful disease characterized by inflammation and the presence of pro-oxidation factors. These pro-oxidation factors are also released when red blood cells (RBCs) lyse. A paper titled “Dapsone hydroxylamine-mediated alterations in human red blood cells from endometriotic patients”…
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By Ezio RosatoNew Molecular Targets for the Treatment of Endometriosis-Associated Pain
By Ezio Rosato
The study identifies potential new targets for alleviating chronic pelvic pain that afflicts many women with endometriosis. A new study published in the scientific journal Redox Biology shows that molecules called microRNAs could be a potential new target to combat…
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Increased Oxidative Stress in Endometriosis may Be Linked to Higher Risk of Ovarian Cancer
By Ezio Rosato
In the study that was published in the scientific journal Translational Oncogenomics, a group of researchers led by Dr. Hariyono Winarto from the Universitas Indonesia in Jakarta identified increased oxidative stress as one of the causes that might explain the…
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